Substantial Intrinsic Merit – The 1st NIW requirement

100% of our National Interest Waiver (EB2) self-sponsored green card petitions were approved in 2017. Attorney fee is $2,900. Submit your resume and google scholar profile link below for a free assessment.

Definition of Substantial Intrinsic Merit

This is generally the easiest of the 3 factors to prove. Working in an area of “substantial intrinsic merit” means work in a field that is valuable to the national interest of the U.S.

Research in any scientific field, for example, can be said to have substantial intrinsic merit to the national interest of the U.S.

Documents required to prove substantial intrinsic merit

In order to prove substantial intrinsic merit, you need to support your statements with proper evidence.

Documentation and statistics must clearly explain in layman’s terms why your field of work is important and what are the practical applications and benefits.

Evidence should prove that your occupation area is of significant national importance and how your work is a national benefit.

Example of proving Substantial Intrinsic Merit:

Our NIW USCIS petition letter would a similar passage to this:

Dr. Smith’s research objective is to use phage peptide-display technology to identify peptide ligands (peptide ligands are short amino acid binding motif that binds to the targets which are expressed in higher amount during the disease) that home (binds) to diseased organ in experimental models of autoimmunity, and use those peptides for molecular imaging and targeted drug delivery system.

Previously, Dr. Smith used these peptides for acute myocardial infraction (heart attack) and T cell delivery in tumors.

Presently, he is employing this innovative technology to identify novel sensing peptides for targeted therapy of experimental multiple sclerosis and systemic lupus erythematosus. The long-term goal of his studies is to develop similar advanced therapies for patients with these diseases.

Molecular Imaging emerged in the early twenty-first century as a discipline at the intersection of molecular biology and in vivo imaging.

It enables the visualization of the cellular function and the follow-up of the molecular process in living organisms non-invasively, without perturbing them, reducing the burden of the long, risky and painful invasive process.

Molecular Imaging may be used as a substitute for invasive procedures, which can sometimes leave large painful wounds that take a long time to heal.

The multiple and numerous potentialities of this field are applicable to the diagnosis of diseases such as cancer, neurological, autoimmunity and cardiovascular diseases.

This technique also contributes to improving the treatment of these disorders by optimizing the pre-clinical and clinical tests of new medication.

They are also expected to have a major economic impact due to earlier and more precise diagnoses.

Molecular and Functional Imaging has taken on a new direction since the description of the human genome.

New paths in fundamental research, as well as in applied and industrial research, render the task of scientists more complex and increase the demands on them.

Dr. Smith’s past and present research shows an enormous facility to drastically improve the research and treatment objectives in the U.S. 

One form of molecular imaging is Near Infrared Imaging (NIR).

Near infrared imaging technologies have undergone rapid growth over the past few decades now play a central role in medical imaging.

But the truly transformative power of imaging in the clinical management of patients lies ahead.

Today, imaging is at a crossroads – molecularly targeted imaging agents are expected to broadly expand the capabilities of conventional anatomical imaging methods.

Molecular imaging will allow clinicians to not only see where a disease is located in the body, but also to visualize the expression and activity of specific molecules (e.g., proteases and protein kinases) and biological processes (e.g., apoptosis, angiogenesis and metastasis) that influence disease behavior and/or response to therapy.

This information is expected to have a major impact on disease detection, individualized treatment and drug development, as well as our understanding of how these complex diseases arise.

Dr. Smith has used the NIR imaging technology to measure apoptosis in the myocardium (layer of heart) in a model of acute myocardial infraction (heart attack).

The second field in which Dr. Smith pursues his research is Targeted drug delivery.

Sometimes called “Smart drug delivery”, it is a method of delivering medication to a patient in a manner that increases the concentration of the medication in the diseased parts of the body compared to normal healthy tissue.

For this useful technology a targeting ligand (a drug is modified in a way so that it can sense the disease, the disease overexpresses particular receptor, a molecular signature, which is sensed by the targeting ligand) is a key essential component.

Peptide ligands are short amino acid binding motif that binds to the targets which are expressed in higher amount during the disease.

The advantages to the targeted release system is the reduction in the frequency of the dosages taken by the patient, having a more uniform effect of the drug, reduction of drug side-effects, and reduced fluctuation in circulating drug levels.

Targeted drug delivery systems have been developed to optimize regenerative techniques.

The system is based on a method that delivers a certain amount of a therapeutic agent for a prolonged period of time to a targeted diseased area within the body.

Dr. Smith successfully used this method to deliver targeted T cells in the tumor model.

To find the binding partners to the molecular signatures expressed in the cells Dr. Smith used technology called Phage display technology –  it is a simple yet powerful technology that is used to rapidly characterize protein- protein interactions from amongst billions of candidates.

This widely practiced technique is engineering peptides, antibodies and other proteins as both diagnostic tools and as human therapeutics.

Dr. Smith used these technologies to identify candidate ligands and use them in molecular imaging and targeted drug therapy (mentioned above).

The homing peptides bind preferentially to these target tissues that carry unique molecular signature, accessible to circulating cells.

Peptide ligands could be organ-selective, or disease selective, but they mainly address the signatures in the endothelial surface of tissue which are undergoing inflammation.

Identification of these binding ligands are peptide sequences, usually 7-12 amino acids, represent the first step towards identifying selective endothelial markers, which is useful in targeting cells, drugs and genes into selected tissues.

One challenge to treating heart and brain diseases lies in the fact that the antibody-based drugs are large in size and cannot penetrate the fine vasculatures, while the peptides have greater promise since they are smaller in size, with better tissue penetration, less possibility of immunogenicity, lesser possibility of liver and bone marrow toxicity, easier processing and lower production cost.

Because they also have fast blood-pool clearance, there are less side effects and they are especially useful in imaging because they give less background noise to signal which easily helps to distinguish disease from a normal healthy condition.

  • Given the prevalence of these complex autoimmune diseases and Dr. Smith’s significant contribution to this field, it is absolutely imperative that his research is sustained. – XXX, Associate Professor of Medicine, University of Maryland, USA (Exhibit 10)
  • T cell-based therapy is highly needed but unmet medical need so far, and over last decade several attempts have been made to achieve the targeted T cell therapies. To resolve this problem. Dr. Smith developed an approach in which he anchored the apoptotic cell-binding peptide ligand to T cell and delivers them to the tumor along with the drug. The on-going apoptosis in the tumor was used as a homing signal to attract more T cells. – XXX, Associate Professor- Department of Pathology, John Hopkins (Exhibit 11) (Independent advisory opinion)
  • Smith described the in vivo imaging signals of myocardial cell death using phage library-derived peptide probe, which binds to apoptotic and necrotic cells. He correlated a long term heart function with imaging signals of myocardial cell death – Dr. XXX Professor, School of Medicine, University of Maryland (Exhibit 9)

Dr. Smith’s research, as discussed above and in more detail below, provides new and potentially groundbreaking ways to save millions of lives claimed by the cardiovascular, cancer, and autoimmune diseases every year.

His work as a researcher already has and will continue to contribute toward the establishment of the U.S. as a global leader in medical science, medical technology, and healthcare, while also creating actual public good.

If you would like a free evaluation in order to determine your chances in obtaining a National Interest Waiver self sponsored EB-2 green card approval, please send us your resume and google scholar citation link by completing the form below:

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  • Please upload your Resume or C.V.

National Interest Waiver – Overview

National Interest Waiver for PhD Students

Physician National Interest Waiver in an Underserved Area

National Interest Waiver – FAQ

National Interest Waiver – Attorney Services

Substantial Intrinsic Merit – The first NIW requirement

Recent National Interest Waiver Approvals

National Interest Waiver Green Card – Step by Step Kit


Client Reviews

They handled our immigration case professionally, and got us through everything. I Highly recommend because I don’t think they’ll be this affordable for so long. Great people too!
Temi Adebayo
Temi Adebayo
19:27 10 Jun 18
Mr. John, Mr. Marc and this firm have been helping me with my immigration needs for the past 12 years. All the time, they have shown very professionalism in handling my filings with USCIS.Their level of service is unmatchable. And, moreover their services are very affordable. They always listened very patiently and answered all my questions and provided the best advice. While filing the papers, they take utmost care to make sure all the information is accurate. I strongly recommend their services.
Db Prakash
Db Prakash
03:26 03 Jun 18
John Dorer at Taylor and Associates provided great service and efficiently helped me accomplish a very challenging legal task. John Dorer's help was terrific! Great job!
Chris Marcell
Chris Marcell
13:03 28 May 18
We hired Marc and John and worked with them for nearly a year and half. They were always patient and extremely helpful at every turn of event. It was a very positive experience working with them.
Wu Jonathan
Wu Jonathan
04:21 15 May 18
Reliable, economical, impeccable work and really fast. They know their work and would ensure every line is true to your details. Will be using their services again and highly recommended!
Geet Divekar
Geet Divekar
00:04 04 May 18
It has been an absolute pleasure working with John and Marc. They have helped and assisted throughout the last 15 years with every single of my work related petition and finally my Green card. Filing petitions with USCIS can be a daunting task but Marc and John have the experience and expertise in filing and assisting employers with several Non Immigrant petitions. I have refereed several of my friends and will continue to do so. Finally, I have three words for this firm. Professional, Efficient and Affordable. The 5 star rating should speak for itself!!
Sushil Pallemoni
Sushil Pallemoni
20:32 02 Apr 18
This is a top notch Green card services Attorney, right from day one i was told correctly in detailed instruction what to do, Online Document upload and constant contact with John Dorer made it a breeze. They are strict discipline guys and expect all the communication and process to be so, so it might feel like they are rude at first, but believe me they are the best and them being strict helps in long run. Documentation to Interview dates, i had to change the address last minute and John made sure that it was done in time even though my application was already out of their office , the recalled and made a correction for me. Take their services, they are top notch in process and will make your life super simple, my MGC application was submitted on 3 Dec 17 and i had a GC in hand by March 18 , Cannot thank them enough for a every step guidance for GC. Thanks Taylor & Associates
Sanjeev Tyagi
Sanjeev Tyagi
05:13 01 Apr 18
I am very thankful to John Dorer, Marc Taylor and the TNA staff for the services provided during my Green Card process from Day 1 to finish. I couldn't ask for more. The lawyer's fee are very reasonable and affordable. They deserve a 5 -star rating and I will absolutely recommend this firm to everyone I know.
Romeo Ranera
Romeo Ranera
15:09 29 Mar 18
Absolute top notch firm for any and all immigration assistance. They assisted me in obtaining my permanent residency and through it all were right there to assist with trouble shooting and complications. Any and all questions were always answered within hours and you’re never left to feel anything less than a top priority as a client. The friendliness and professionalism with which they operate is A1 and I wouldn’t have been able to navigate the complications of USCIS without Marc and John. Highly recommend anyone seeking assistance to contact them!
Vanessa Nolan
Vanessa Nolan
21:05 21 Mar 18
I was very pleased with their professional service from the beginning to the end for my citizenship application. I am a professional working in the higher education and somewhat familiar with the immigration process. For that reason, I was thinking of applying it by myself but I found Taylor and Associates whose service fee is very affordable and worth of my time. Indeed, they found some of minor mistakes in my application, which could have delayed much longer for my application process. Luckily, they caught and fixed them immediately. Their communication was excellent. In fact, everything was very smooth. Even after I had the approval notice, they followed up with valuable advices. I strongly recommend their service if you need immigration services. Thank you Marc and John for your excellent services.
Dominic Choo
Dominic Choo
17:12 23 Dec 17
my wife and i worked with John Dorer from Marc Taylors Associates. He's services were awesome and amazing. i would recommend him to anybody applying for their permanent resident to work with them.
Seun Olanrewaju
Seun Olanrewaju
15:33 22 Dec 17
Used the services of this office for Green Card through AOS and was mainly in contact with John Dorer. I was unsure about their services at first, considering the unusually affordable cost but was pleasantly surprised by their prompt responses to all our questions and their timely preparing and handling of our documents! Will be using their services again when filing for removal of condition! Definitely recommended!
Lisa Lorentzon
Lisa Lorentzon
22:56 10 Dec 17
Marc and John helped me apply and get my green card. They are very specific about needed documents and other details. Also, they are very responsive when you have a question. I know I emailed them several times just to ask questions that I could have found answers online myself. They are very patient and professional. If you want to get great services with reasonable fees contact them!
Amin Bagheri
Amin Bagheri
11:54 12 Oct 17
My husband and I worked with John Dorer from Marc Taylor's office, and his services exceeded our expectations. He was very knowledgeable, responsive, and our Green Card process and interview from start to finish went smoothly. Thank you so much, John, for your dedication to our case and all your help. I would highly recommend USAVISANOW to all!
Sophia Nguyen
Sophia Nguyen
17:26 09 Oct 17
The best law agency I have ever worked with. Very responsive, experienced. I trusted my green process to them and it was done perfectly without and issues in minimum possible period. Thank You Very much Marc, John and others!!!
Hrach Gyulzadyan
Hrach Gyulzadyan
16:38 30 Sep 17
USVISANOW streamlined the paperwork which saved us so much time. This also reduced the stress involved in filling out the paperwork. They also are very understanding and respond very quickly to questions and emails. Jackline is now a US citizen which took less than 5 months. Thank you Mr. Taylor and your team. From Brian and Jacky.
Jackline Osero
Jackline Osero
17:32 12 Sep 17
Mark and team went above all my expectations of an 'online' service agency I went in with very low expectations to match the low cost of the service and was amazed that the experience was no different than going through an expensive attorney. They were very prompt on responses, very patient and also very knowledgeable on every facet of the application (including a follow up checklist). I would highly recommend them considering the low cost they charge and the high risk we take by doing this ourselves
First Dhalsite
First Dhalsite
22:27 01 Sep 17
I am US citizen. We hired Marc's firm for my wife's Green Card process, We are extremely happy with their services.They are one of the best service providers in the country. Price is very affordable. John is awesome. He responded to our queries on time with very useful information. We highly recommend this firm to anybody looking for affordable and the best immigration services. it was an awesome experience working with this team.
Narsimha M
Narsimha M
13:57 04 Aug 17
At first I thought I could have very well gone through the green card application process on my own and saved all lawyer fees. Its funny how some lawyers can charge in excess of 2K for this. However at Taylor and Associates the price seemed more reasonable and felt it made sense to go with one at that price. There were some doubts that arose in our mind which they cleared in a timely manner and seemed very knowledgeable in this area. Its for moments like these when having a professional around helps. While we can get busy with our lives and with laws constantly changing, I would definitely recommend them - a small price to pay for peace of mind.
Callistus Pereira
Callistus Pereira
17:51 06 Jun 17
I've had the pleasure of conducting business with this law firm for the last 10 years. They have been nothing but the best for every aspect of immigration need I had. From F1 all the way to citizenship. They're probably the most affordable, knowledgeable, and most efficient immigration law firm out there. Plus, they always provide responses to questions in a very timely manner. Trust me, other immigration law firms will cost you an arm and a leg for the same or less of a service compared to this law firm. Give them a call, check out their website. You will not regret it.
Andy Glasgow
Andy Glasgow
17:26 27 Mar 17
Because of John and his team my wife and I were able to travel back to the states, get married and have a Green Card without any headaches. John’s efforts were amazing and it shows because my wife and I didn’t have to go to the Green card interview. We had a strong enough case to receive the Green card in the mail. If you’re seeking a Lawyer that will be impartial, he’s your guy.
19:18 23 Feb 17
Marc and John Dorer worked on our case to file for AOS after our L1A was approved.Marc and John are professionals and extremely reasonable-priced. The reason they are able to cut the price is because they don't spend time consulting you or guiding you and will never get on call.All communications are email only, so if you know precisely what you want they will do all the paper-work, follow the trail and get the job done. If you are confused and need advice and consulting, they may not be the right lawyers.But since we were doing our AOS, it worked out perfectly well and they did their job extremely professionally.Would recommend them every time to get the work done.
hardik parikh
hardik parikh
01:58 08 Feb 17
Me & husband went through immigration process which thankfully was made easy with the help and services of Marc Tyler Inc. Our direct contact was John which i want to personally say Thank You ! The service provided was efficient, fast, affordable prompt answers in a timely fashion. I would recommend Marc Tyler Inc to anyone who need immigration done fast, easy, friendly & with no hidden charges.
Aleksandra Stoycheva
Aleksandra Stoycheva
15:27 26 Jan 17
I could not have asked for better service. I will definitely be coming back to get the green card process done. The fees are extremely reasonable and they stick with their clients the entire way. I had so many questions during this process, and each one of them were answered very quickly and with out most professionalism. This firm is a pleasure to work with and I highly recommend them to anyone.
bryan mowrey
bryan mowrey
06:41 25 Nov 16

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